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September 5, 2025AJP Gastrointestinal and Liver PhysiologyOpen Access

Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and Ferroptosis

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Authors

PCPeyton ClassonAWAlexander Q. WixomNMNatalia Calixto Mancipe

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Overview

Observational analysis reveals diverse ACSL expression and its implications in MASH-HCC, suggesting potential new therapeutic targets.

Key Points

  • ACSL4 expression correlates with increased ferroptosis sensitivity in hepatocellular carcinoma cells, highlighting a potential therapeutic target.
  • High expression of ACSL4 was notable in tumor tissues of MASH-HCC, while ACSL5 was found elevated in non-cancerous areas.
  • Analysis combined bulk RNA-sequencing, single-cell techniques, and immunohistochemistry to examine lipid metabolism in MASH-HCC.
  • The study emphasizes the lipid metabolic landscape's role in cancer progression and possible vulnerabilities for treatment strategies.

Cite This Study

Classon et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef02b87ece8dc95742ehttps://doi.org/10.1152/ajpgi.00096.2025
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer2018 · 590 citations
  2. 2Myeloid-Specific Deficiency of <i>Long-Chain Acyl CoA Synthetase 4</i> Reduces Inflammation by Remodeling Phospholipids and Reducing Production of Arachidonic Acid–Derived Proinflammatory Lipid Mediators2021 · 26 citations
  3. 3MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis2023 · 64 citations