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September 5, 2025Blood PurificationOpen Access

Current Knowledge on the Impact of Extracorporeal Blood Purification Devices on Drug Clearance – Systematic Search & Narrative Review

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Authors

RPRajib PaulAAAbdul Samad AnsariDBDavid Ballesteros

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Overview

Systematic review shows effects on drug clearance in sepsis management, suggesting careful monitoring is needed.

Key Points

  • Adsorptive EBP devices can unintentionally remove drugs, compromising therapeutic effectiveness in critically ill patients.
  • Among the devices studied, CytoSorb had the most comprehensive data, with 25 relevant publications reported.
  • A systematic search across multiple databases was performed, identifying 61 studies that met inclusion criteria.
  • Therapeutic drug monitoring is essential to guide clinical decisions and optimize therapy for patient safety.

Cite This Study

Paul et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef02b87ece8dc9575ebhttps://doi.org/10.1159/000547477
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