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September 5, 2025CephalalgiaOpen Access

Effectiveness and tolerability of atogepant as preventive treatment in resistant individuals with chronic migraine: Six-month real-world evidence

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Authors

ARAntonio RussoMSMarcello SilvestroIFIan Finkelstein

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Overview

Prospective study shows atogepant improves migraine days in chronic migraine patients, indicating effective preventive treatment.

Key Points

  • Atogepant reduced monthly migraine days by 7.1 days over six months, evidencing its effectiveness in chronic migraine treatment.
  • Among participants, 53% achieved at least a 50% reduction in monthly migraine days at 24 weeks, highlighting a significant response rate.
  • Participants experienced improved headache impact scores and reduced acute medication intake, indicating better overall management of their condition.
  • Despite treatment-emergent adverse events reported by 53%, the benefits of atogepant in treatment-resistant chronic migraine patients were significant.

Cite This Study

Russo et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef72b87ece8dc957875https://doi.org/10.1177/03331024251370608
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