Case report demonstrates colchicine induces remission in a child with generalized pustular psoriasis, suggesting alternative to biologics.
Generalized pustular psoriasis is uncommon in children and therapy is typically with systemic agents. While many drugs like oral retinoids, cyclosporine, methotrexate, and spesolimab are used, colchicine is a safe and underutilized drug that acts by inhibition of neutrophils and the TNF-α-NF-kβ pathway. We report a case of a 10-year-old with generalized pustular psoriasis refractory to cyclosporine and methotrexate who achieved complete remission within 6 weeks of colchicine monotherapy.
No takes yet. Share an insight, caveat, or question.
Sharath et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: