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September 5, 2025Brain SciencesOpen Access

Clinical Relevance of Peripheral Interleukins in Drug-Naive First-Episode Psychosis: Symptom-Specific Associations from the PANSS Dimensions

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Authors

IBIva BinićJPJovana PetrovićOŽOlivera Žikić

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Overview

Observational analysis showed elevated interleukins in first-episode psychosis patients, highlighting immune dysregulation's role.

Key Points

  • Elevated serum levels of IL-1β, IL-2, and IL-10 were found in first-episode psychosis patients compared to controls.
  • IL-2 demonstrated the highest discriminatory power with an AUC of 0.917, suggesting its potential as a biomarker.
  • Cytokine levels correlated with specific PANSS symptoms, indicating immune dysregulation's impact on psychotic presentations.
  • The findings support the need for further longitudinal studies to establish the prognostic significance of these biomarkers.

Cite This Study

Binić et al. (2025) studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957b11https://doi.org/10.3390/brainsci15090932
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytokines in First-Episode Psychosis: Implications for Pathophysiology: A Narrative Literature Review2026
  2. 2Inflammatory Factors in Early Stages of Psychosis2025
  3. 3Antipsychotics Lower Peripheral Markers of Inflammation in Drug-naive Early Psychosis: A Pilot Study2025
  4. 4Antipsychotics lower peripheral markers of inflammation in drug-naïve early psychosis: a pilot study2026
  5. 5Plasma concentrations of IL-8, IFN-γ and IL-1β in schizophrenia patients with subgroup analysis of first episode drug naïve patients2024