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Effect of Antioxidative Activity and Inhibition of Melanogenesis from Euphorbia humifusa Extract

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The ethyl acetate fraction inhibited melanin production by 73% in B16/F10 melanoma cells treated with α-MSH.
DPPH assay results show the ethyl acetate fraction had antioxidant activity 24.1 times better than the control.
Intracellular tyrosinase activity decreased by 45% with the ethyl acetate fraction at 100 μg/mL compared to α-MSH alone.
The study underscores the potential of Euphorbia humifusa extract for developing natural skin whitening products.

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Experiments demonstrate that ethyl acetate fraction reduces melanin production in melanoma cells, suggesting potential for skin whitening.

Kang et al. (2025) studied this question.

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Experiments demonstrate that ethyl acetate fraction reduces melanin production in melanoma cells, suggesting potential for skin whitening.