Observational analysis shows high encapsulation efficiency of resveratrol in soybean lipophilic protein nanoparticles, indicating improved nutritional delivery.
This study investigated the structure, interfacial properties, and digestibility of resveratrol (Res)-loaded soybean lipophilic protein (LP) nanoparticles using a urea-induced disassembly–reassembly approach. Structural analysis confirmed that LP partially restored its secondary to quaternary structures during dialysis, verifying the reversibility of structural reassembly. Analysis of LP–Res nanoparticles showed that increasing urea concentration ([U]) led to the highest encapsulation efficiency (88.32%) and loading capacity (15.91 μg/mg) at 8 M urea. Meanwhile, characterization of interfacial properties indicated that Res-loaded LP–Res nanoparticles improved interfacial features and foam stability, especially under 8U-Res conditions. Furthermore, dynamic in vitro digestion results demonstrated that 8U-Res nanoparticles exhibited sustained release and the highest digestibility (77.8%). These findings reveal the close relationship between LP structural recovery and interfacial functionality, supporting its application as a nanocarrier in nutritional delivery systems.
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Zhong et al. (2025) studied this question.
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