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September 5, 2025Journal of Cachexia Sarcopenia and MuscleOpen Access

Characterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy

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Authors

HZHonglin ZhuYXYizhi XiaoSXShasha Xie

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Overview

This analysis of IIM reveals diverse cell types and their prognostic value, suggesting key clinical implications.

Key Points

  • Significant shifts in cell subpopulations in IIM muscle tissues may contribute to muscle damage and affect disease outcomes.
  • Elevated cytotoxic CD56 dim CD16 dim NK cells were linked to severe muscle damage, indicating potential therapeutic targets.
  • Reduced angiogenesis-related SERPINB2 + monocytes predicted better outcomes in immune-mediated necrotizing myopathy.
  • Analysis using single-cell RNA sequencing revealed diverse immune cell types across different IIM subtypes, emphasizing the complexity of the disease.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957e55https://doi.org/10.1002/jcsm.70043
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single‐cell transcriptomic analysis on multi‐subtypes of idiopathic inflammatory myopathy reveals pathological hallmarks associated with stromal stem and immune cells in damaged skeletal muscles2026
  2. 2Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies2025 · 8 citations
  3. 3Differentiating idiopathic inflammatory myopathies by automated morphometric analysis of MHC‐1, MHC‐2 and ICAM‐1 in muscle tissue2024 · 4 citations
  4. 4Semi-quantitative analyses of muscle magnetic resonance imaging for pattern recognition in early idiopathic inflammatory myopathies2026
  5. 5Clinicopathological and serological spectrum of idiopathic inflammatory myopathies: Experience from a neuromuscular referral center in Cyprus2026