AI to the Rescue: Fighting Atrial Fibrillation With Code

Journal of Cardiovascular ElectrophysiologyEarly View INVITED EDITORIAL AI to the Rescue: Fighting Atrial Fibrillation With Code Kathryn E. Mangold, Kathryn E. Mangold orcid.org/0000-0001-7048-2699 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USASearch for more papers by this authorLinda Johnson, Linda Johnson orcid.org/0000-0002-2249-8220 Department of Clinical Sciences, Malmö, Lund University, Lund, SwedenSearch for more papers by this authorAbhishek Deshmukh, Corresponding Author Abhishek Deshmukh [email protected] Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA Correspondence: Abhishek Deshmukh ([email protected])Search for more papers by this author Kathryn E. Mangold, Kathryn E. Mangold orcid.org/0000-0001-7048-2699 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USASearch for more papers by this authorLinda Johnson, Linda Johnson orcid.org/0000-0002-2249-8220 Department of Clinical Sciences, Malmö, Lund University, Lund, SwedenSearch for more papers by this authorAbhishek Deshmukh, Corresponding Author Abhishek Deshmukh [email protected] Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA Correspondence: Abhishek Deshmukh ([email protected])Search for more papers by this author First published: 27 August 2025 https://doi.org/10.1111/jce.70084Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechatBluesky No abstract is available for this article. References 1D. Ko, M. K. Chung, P. T. Evans, E. J. Benjamin, and R. H. Helm, "Atrial Fibrillation: A Review," Journal of the American Medical Association 333, no. 4 (2025): 329–342. 10.1001/jama.2024.22451 CAS Web of Science® Google Scholar 2A. Deshmukh, M. Iglesias, R. Khanna, and T. Beaulieu, "Healthcare Utilization and Costs Associated With a Diagnosis of Incident Atrial Fibrillation," Heart Rhythm O2 3, no. 5 (2022): 577–586. 10.1016/j.hroo.2022.07.010 PubMed Web of Science® Google Scholar 3Z. I. Attia, D. M. Harmon, E. R. Behr, and P. A. Friedman, "Application of Artificial Intelligence to the Electrocardiogram," European Heart Journal 42, no. 46 (2021): 4717–4730. 10.1093/eurheartj/ehab649 CAS PubMed Web of Science® Google Scholar 4Z. I. Attia, P. A. Noseworthy, F. Lopez-Jimenez, et al., "An Artificial Intelligence-Enabled ECG Algorithm for the Identification of Patients With Atrial Fibrillation During Sinus Rhythm: A Retrospective Analysis of Outcome Prediction," Lancet 394, no. 10201 (2019): 861–867. 10.1016/S0140-6736(19)31721-0 PubMed Web of Science® Google Scholar 5X. Yao, Z. I. Attia, E. M. Behnken, et al., "Realtime Diagnosis From Electrocardiogram Artificial Intelligence- Guided Screening for Trial Fibrillation With Long Follow-Up (REGAL): Rationale and Design of a Pragmatic, Decentralized, Randomized Controlled Trial," American Heart Journal 267 (2024): 62–69. 10.1016/j.ahj.2023.10.005 CAS PubMed Google Scholar 6T. Y. Chang, S. P. Chen, J. H. Hsieh, et al., "Artificial Intelligence-Enabled Short-Term Ambulatory Monitoring ECG During Sinus Rhythm for Prediction of Hidden Atrial Fibrillation," Journal of Cardiovascular Electrophysiology, ahead of print, July 25, 2025, https://doi.org/10.1111/jce.70028. 10.1111/jce.70028 Web of Science® Google Scholar 7J. Petch, S. Di, and W. Nelson, "Opening the Black Box: The Promise and Limitations of Explainable Machine Learning in Cardiology," Canadian Journal of Cardiology 38, no. 2 (2022): 204–213. 10.1016/j.cjca.2021.09.004 PubMed Web of Science® Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation