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September 5, 2025Open Access

The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity

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Authors

SJShunying JinUniversity of LouisvilleRSRicha SinghalUniversity of LouisvilleJLJie LuoGuizhou Normal University

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Implication

Research reveals Nox2 regulates inflammatory responses in the oral cavity, suggesting Nrf2's influence on neutrophils.

Key Points

  • Nox2 deficiency leads to uncontrolled neutrophilic inflammation, worsening oral tissue damage.
  • Significant cytokine upregulation was observed in oral tissues from Nox2-deficient mice.
  • Nrf2 activity modulation can alleviate hyperinflammatory responses in oral tissues.
  • Chronic granulomatous disease patients often suffer from recurrent oral ulcers and stomatitis.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68bb42142b87ece8dc958563https://doi.org/10.1101/2025.08.26.671820
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