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Efficacy of melatonin and letrozole combination therapy compared to letrozole alone in the treatment of symptomatic endometrioma in infertile women

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Randomized controlled trial shows similar pain reduction with melatonin and letrozole, indicating comparable benefits for endometriosis treatment.

Mean VAS score significantly decreased with both therapies, indicating pain reduction.
Size of endometrioma showed a reduction in both treatment groups after three months.
No statistically significant difference in efficacy was found between the combined and single therapies.
The study involved 40 infertile women with symptomatic endometrioma.

Khatun et al. (2025) studied this question.

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Randomized controlled trial shows similar pain reduction with melatonin and letrozole, indicating comparable benefits for endometriosis treatment.