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September 5, 2025Open Access

MNase stratification reveals heterogeneous 5hmC in naive B cells

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Observational analysis identified unique 5hmC subsets in naive B cells, highlighting nucleosome interactions with chromatin features.

About 95% of 5hmC peaks remain after MNase digest, indicating strong nucleosome association.
Accessible 5hmC at promoters correlates more closely with gene expression than total 5hmC levels.
The MNase-sensitive 5hmC subset is about 3%, suggesting it plays a distinct regulatory role in gene activation.
Protected 5hmC, enriched in mixed chromatin states, indicates potential regulatory complexities of 5hmC.

Hsu et al. (2025) studied this question.

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