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September 5, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Functionalized metal-organic framework and MOF-derived materials for bone regeneration applications

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Authors

YFYubo FanCross-Cutting CardiologyCLC. N. H. LongRoyal College of Surgeons of EnglandYCYingying CaiWenzhou Medical University

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Overview

This review highlights the applications of metal-organic frameworks in bone regeneration, suggesting significant advancements in biocompatibility and osteogenic mechanisms.

Key Points

  • Bone regeneration applications of metal-organic frameworks show improved outcomes in preclinical studies, addressing challenges in conventional grafts.
  • The review discusses synthesis methods like solvothermal and ultrasonic techniques, enhancing the physical properties of MOFs for bone applications.
  • Osteogenic mechanisms such as controlled drug delivery and anti-inflammatory effects contribute to the promising performance of MOFs in healing bone defects.
  • Key challenges like cytotoxicity and long-term biosafety are outlined, with future strategies focusing on smart scaffolds for personalized medical solutions.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68bb42212b87ece8dc958a41https://doi.org/10.3389/fbioe.2025.1645657
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