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September 5, 2025Kuban Scientific Medical BulletinOpen Access

Blister fluid as a source of steroid resistance biomarkers in patients with life-threatening bullous dermatoses: An observational cohort controlled study

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Authors

OOOlga Yu. OlisovaALAnfisa A. LepekhovaАДА. С. Духанин

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Overview

Observational cohort study reports cytokine and granulysin profiles in blister fluid, suggesting potential biomarkers for steroid resistance.

Key Points

  • Statistically higher levels of cytokines and granulysin in serum of bullous dermatoses patients indicate inflammatory response.
  • Lower tumor necrosis factor-α levels in blister fluid correlate with steroid resistance in pemphigus vulgaris patients.
  • Analysis of blister fluid can identify biomarkers associated with steroid resistance in bullous dermatoses.
  • Findings emphasize the need for differential diagnosis and may improve treatment strategies for severe skin diseases.

Cite This Study

Olisova et al. (2025) studied this question.

synapsesocial.com/papers/68bb42272b87ece8dc958d53https://doi.org/10.25207/1608-6228-2025-32-4-62-81
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