This method demonstrates improved peptide synthesis yields in the context of antibody-drug conjugates, suggesting enhanced efficiency.
The synthesis of peptide‐based linkers for antibody‐drug conjugates involves an oxidative decarboxylation step. Traditional Hofer–Moest electrolysis conditions are not suitable to achieve this transformation due to the presence of an oxidatively labile Fmoc‐protecting group. Herein, a solvent‐enabled electrochemical procedure has been established, whereby the solvent electrochemical window prevents degradation of the protecting group. The method has been demonstrated for several relevant peptides in good to very good yields (64–92%).
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Köpfler et al. (2025) studied this question.
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