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Design, Synthesis, and Antimicrobial Evaluation of Short Hybrid Peptides Incorporating Β- And Γ-Amino Acids for Membrane-Targeted Activity Against Multidrug-Resistant Bacteria

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Synthesis of short hybrid peptides shows potent membrane-targeted activity against MDR bacteria, indicating new therapy options.

P2, P3, P4, and P5 exhibited bactericidal effects against Gram-positive and Gram-negative MDR strains that reduced bacterial viability rapidly.
Minimum inhibitory concentrations for effective peptides were as low as 6.25 μM, demonstrating their potency against resistant strains.
Peptides synthesized using lipidation and confirmed with NMR and HRMS methods, improving their pharmacokinetic properties.
The study suggests that these hybrid peptides could provide effective treatment alternatives for multidrug-resistant infections, balancing efficacy and low toxicity.

Archana Shaha (2025) studied this question.

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Authors

Synthesis of short hybrid peptides shows potent membrane-targeted activity against MDR bacteria, indicating new therapy options.

P2, P3, P4, and P5 exhibited bactericidal effects against Gram-positive and Gram-negative MDR strains that reduced bacterial viability rapidly.
Minimum inhibitory concentrations for effective peptides were as low as 6.25 μM, demonstrating their potency against resistant strains.
Peptides synthesized using lipidation and confirmed with NMR and HRMS methods, improving their pharmacokinetic properties.
The study suggests that these hybrid peptides could provide effective treatment alternatives for multidrug-resistant infections, balancing efficacy and low toxicity.

Archana Shaha (2025) studied this question.

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