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September 5, 2025Neuro-Oncology AdvancesOpen Access

55 Insights Into Meningioma Biology and Radiotherapy Response Through Molecular Characterization of Rtog-0539 Clinical Trial

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Authors

LYLeeor S. YefetUniversity Health NetworkALA P LandryJWJames Z. WangPennsylvania State University

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Overview

Observational analysis identifies molecular correlates of radiotherapy response in meningiomas, highlighting precision medicine implications.

Key Points

  • High-risk meningiomas exhibit significant cell cycle dysregulation with specific genomic alterations involved.
  • Notable alterations like 1p loss and 1q gain correlate with aggressive tumor behavior in meningiomas.
  • Multi-omic integration allowed for refined risk stratification beyond traditional histopathologic grading.
  • These findings support ongoing precision medicine trials by emphasizing prospective tumor banking for better treatment strategies.

Cite This Study

Yefet et al. (2025) studied this question.

synapsesocial.com/papers/68bb46b56d6d5674bccfe703https://doi.org/10.1093/noajnl/vdaf166.051
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Also Consider

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  1. 1Modern Molecular Profiling Recontextualizes the NRG/RTOG 0539 Trial and Reveals Hidden High-Risk and Radiotherapy Resistant Meningiomas2026
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