Cross-sectional analysis shows increased immunological markers and reduced vitamin D3 in osteoporosis patients, suggesting underlying systemic changes.
Background: Osteoporosis is a degenerative, progressive bone condition that causes widespread fragility and an increased risk of fractures. This study was designed to determine some levels of Immunological parameters, such as Interleukin (IL) IL-17, IL-1, IL-15, IL-6, Hematological parameters (Hb and WBC), and some biochemical parameters (Vit D3) in patients with osteoporosis and compare their parameter levels with the control group. Methodology: This cross-sectional study was conducted among the general population who attended Ramadi Teaching Hospital in Ramadi city from the 1st of November 2023 to the 1st of January 2024. The total number of blood samples were 80 samples which are included 50 samples for patients with osteoporosis with ages ranging from 16 to 50 years and 30 samples for healthy individuals as a control group. Results: There was significant deference in all parameters with p-value (<0.05), the means levels of IL-1, IL-17, IL-15, IL-6 and Vit D3 respectively were: (8.467pg), (89.32pg), (83.84pg), (60.34pg), (4.667pg); As well as the concentration of Hb, and mean number of WBC were: Hb(9.16g/dL) and\ WBC(14.19*103 c/ mm3) respectively. Conclusion: We conclude that patients suffering from osteoporosis showed a significant increase in the levels of IL-1, IL-17, IL-15, IL-6, and WBC compared with controls. However, there was a significant decrease in vitamin D3 and Hb in patients compared to controls.
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Mohammed et al. (2025) studied this question.
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