This protocol demonstrates synthesis of acridine derivatives using DABCO as catalyst and glycerol as solvent, implying eco-friendly practices.
In this protocol we investigate a feasible study concerning synthesis of 9-(2-Chlorophenyl)-3,3,7,7-tetramethyl-10-phenyl 3,4,4a 7,8,9a,10-octahydroacridine-1,5(2H,6H)-dione derivatives. Synthesis has been done in presence of DABCO as catalyst and glycerol as solvent. Presence of DABCO induced a remarkable acceleration to the three component sequential reaction between aldehyde, dimedone and aniline. Consequently, these types of protocol could be considered eco-friendly and derivatives are synthesised from good to excellent yield
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Divya Srivastava (2025) studied this question.
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