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September 5, 2025Open Access

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

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Authors

ABAbrar BhatADAmit DasMIMeera Iyer

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Overview

Kinetic study reveals active flows drive affinity-based sorting in membrane proteins, highlighting cellular composition control.

Key Points

  • Affinity-based sorting mechanism influences membrane composition, emphasizing the role of active flows.
  • Kinetic Monte Carlo simulations show interplay between actin-binding affinity and cluster formation.
  • In vivo observations reveal sorting between high and low-affinity actin-binders during cell spreading.
  • The research finds that active cortical meshwork engagement controls local membrane protein assembly.

Cite This Study

Bhat et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfeea3https://doi.org/10.1101/2025.08.29.673170
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