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February 20, 2026Molecular Biology of the Cell

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex

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Authors

GSGregory J. SchwarzJSJoanna R. SuberDADevika Andhare

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Overview

Experiments demonstrate how membrane composition influences F-actin dynamics in artificial cell cortex, suggesting new regulatory mechanisms.

Key Points

  • This research investigates how membrane composition affects the dynamic patterning of Rho and F-actin in an artificial cell cortex.
  • Used an artificial cell cortex made from Xenopus laevis egg extract and supported lipid bilayers.
  • Manipulated levels of specific lipids including phosphatidylinositol 4,5-bisphosphate and sphingomyelin.
  • Analyzed dynamics of traveling waves and oscillations of active Rho and F-actin.
  • Altered lipid composition significantly changed Rho activation kinetics.
  • Diverse lipid levels modified the dynamics of F-actin assembly and cortical patterning.
  • Demonstrated a direct link between membrane composition and assembly patterns of F-actin.

Cite This Study

Schwarz et al. (2026) studied this question.

synapsesocial.com/papers/6997fa35ad1d9b11b345339chttps://doi.org/10.1091/mbc.e25-07-0362
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