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February 21, 2026Biophysical Journal

BPS2026 – Computational modeling of cortical actomyosin flows and polarization in mammalian eggs after fertilization

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Authors

JCJeffery CoulterTKTaeyoon Kim

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Overview

Computational modeling reveals calmodulin involvement in polarization and polar body emission in fertilized mammalian eggs.

Key Points

  • The aim is to elucidate factors driving cortical flow and polarization in fertilized mammalian eggs.
  • Developed a hybrid computational model simulating cortical networks and biochemical pathways in 3D.
  • Correlated cytoskeletal factors with spatiotemporal activities of RhoA and calmodulin.
  • Analyzed the impact of signal frequency and duration on cortical flow toward polar body regions.
  • Identified the role of calmodulin in regulating cortical polarization during fertilization.
  • Demonstrated the significance of cytosolic calcium increases in driving cytoplasmic movement.
  • Provided insights into the early developmental processes in mammalian eggs.

Cite This Study

Coulter et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac28d5https://doi.org/10.1016/j.bpj.2025.11.2518
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