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February 21, 2026Biophysical Journal

BPS2026 – Unveiling the mechanism of cortical actin flows during cytokinesis

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Authors

FLFahmida Sultana LaboniFRFrancois B. RobinTKTaeYoon Kim

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Overview

Simulation reveals dynamics of cortical actin flows in cytokinesis, suggesting molecular mechanisms influence cell division.

Key Points

  • This research aims to unveil the mechanisms driving cortical actin flows during cytokinesis.
  • Utilized an agent-based computational model for a two-dimensional actomyosin network with a cell membrane.
  • Simulated conditions to reproduce cortical flow dynamics.
  • Analyzed dependence on molecular parameters like myosin motors and cross-linking proteins.
  • Successful reproduction of cortical flow dynamics in simulations.
  • Cortical flow emergence is influenced by the densities of myosin motors and cross-linking proteins.
  • Insights into how molecular-scale interactions lead to cell-scale behaviors.

Cite This Study

Laboni et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac29b8https://doi.org/10.1016/j.bpj.2025.11.2526
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