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This study aims to clarify whether actin filament recruitment during cytokinesis is random or directional.

Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments.

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This study aims to clarify whether actin filament recruitment during cytokinesis is random or directional.
Microinjected actin filaments were labeled with fluorescent phalloidin to track movements in NRK cells.
Distribution of actin filaments was observed during prometaphase to telophase phases of cell division.
Fluorescence intensity and movements of actin aggregates were analyzed at specific time intervals.
Actin filaments were primarily cytoplasmic at prometaphase and metaphase, moving to the cortex prior to anaphase.
Movement of cortical actin toward the equatorial region was detected at an average rate of 1.0 micron/min during anaphase and telophase.
Concentration of actin increased at the equatorial region while decreasing at polar regions shortly after anaphase onset.

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Randomized trial observes actin filament movements in NRK cells, indicating dynamics during division.

Cao et al. (1990) studied this question.

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