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September 5, 2025The Journal of Toxicological SciencesOpen Access

Ionic liquid cytotoxicity in mouse macrophage J774.1 cells: Effects of alkyl chain length, cation core, and anion type

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Authors

TNTakahito NishiyamaRSRyousuke SudaTHT. Hirokawa

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Overview

This research assesses cytotoxicity in mouse macrophage cells, indicating ionic liquid cation core and anion type significantly impact toxicity.

Key Points

  • Cytotoxicity increased with longer alkyl chains in ionic liquids, revealing a significant structural influence on toxicity.
  • The cationic species showed lower ED50 values, indicating higher toxicity in phosphonium compared to ammonium derivatives.
  • Ionic liquid toxicity differed based on the anion, but varying anion types had no significant effect on some cation combinations.
  • Findings highlight the importance of understanding the structural properties of ionic liquids for safer applications in biochemical contexts.

Cite This Study

Nishiyama et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfef39https://doi.org/10.2131/jts.50.483
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