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September 5, 2025Jundishapur Journal of MicrobiologyOpen Access

Genotyping and Molecular Analysis of Carbapenem-Resistant Acinetobacter baumannii: Correlations Between Antibiotic Resistance and Virulence Genes

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Authors

HEHaniye EsfandiyariIslamic Azad University South Tehran BranchMFMaedeh FarhaniIslamic Azad University South Tehran BranchZHZoheir HeshmatipourIslamic Azad University Tonekabon

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Overview

Observational analysis finds 87.5% of Acinetobacter baumannii isolates resistant to multiple antibiotics, indicating significant virulence gene presence.

Key Points

  • 87.5% of the Acinetobacter baumannii isolates were resistant to multiple antibiotics, highlighting the severity of the issue.
  • The predominant carbapenemase genes found were blaOXA-51, blaOXA-24, and blaOXA-58, indicating strong genetic resistance mechanisms.
  • 95% of isolates carried virulence-associated genes such as recA, ompA, and lipA, which are crucial for infection capability.
  • The genetic analysis revealed both closely related strains and diverse isolates, pointing to potential hospital transmission and varied sources.

Cite This Study

Esfandiyari et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfefe3https://doi.org/10.5812/jjm-162057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Between Antibiotic Resistance Patterns and Analysis of Virulence Genes in Multi-drug Resistant <i>Acinetobacter baumannii</i> in Iran (2018)2025 · 1 citations
  2. 2Resistance Mechanisms Of Acinetobacter Baumannii In North Indian Clinical Isolates: A Molecular Study Of Β-Lactam, Carbapenem, Cephalosporin, Fluoroquinolone, And Aminoglycoside Genes2025
  3. 3Molecular Analysis of Gene Collections Associated with Carbapenem-Resistant Acinetobacter baumannii: Systematic review2025
  4. 4Persistence of Carbapenem-Resistant Acinetobacter baumannii in intensive care units environment2024
  5. 5Genotypic Detection of Carbapenems Resistance Genes in Acinetobacter baumannii Isolated from Urinary Tract Infection Patients2024