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September 5, 2025Ophthalmologica IndonesianaOpen Access

Diffuse Granulomatous Conjunctivitis as an Ocular Manifestation of ANCA-Negative Limited Wegener’s Granulomatosis: A Case-Based Literature Review

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Authors

CHCindy HartonoAPAndi PratiwiNSNi Ketut Sungowati

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Overview

Case report highlights granulomatous conjunctivitis in an ANCA-negative child, suggesting diagnostic challenges in Wegener’s granulomatosis.

Key Points

  • A pediatric case revealed ocular manifestations of Wegener's granulomatosis, despite negative ANCA results.
  • The biopsied conjunctiva showed necrotizing granulomas with significant leukocyte infiltrate consistent with the disease.
  • Granulomatous conjunctivitis can present in limited forms of Wegener's granulomatosis, requiring careful diagnostic evaluation.
  • Clinical suspicion and tissue biopsy are critical for diagnosing ANCA-negative cases of granulomatous vasculitis.

Cite This Study

Hartono et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c96d6d5674bccff08ehttps://doi.org/10.35749/journal.v51i2.101588
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