Key result
Early diagnosis and instigation of immunosuppressants such as cyclophosphamide can induce long-term remission in Wegener's granulomatosis.
Wegener's granulomatosis is a systemic inflammatory disease diagnosed by a classic triad and C-ANCA, which can be treated with immunosuppressants like cyclophosphamide to induce long-term remission.
Early recognition of ocular WG may improve survival; leaves open optimal immunosuppression protocols in limited disease.
Wegener's granulomatosis (WG) is a systemic granulomatous inflammatory disease of unknown origin. It occurs at any age, with the peak incidence in the third and fourth decades. The classic diagnostic triad of WG is necrotising granuloma of the upper or lower respiratory tract, vasculitis, and nephritis. Identifying a raised ANCA titre is virtually diagnostic of the disease, especially with the classic granular cytoplasmic staining pattern of neutrophils (C-ANCA). 1 This disease is usually fatal if untreated; however, early diagnosis and instigation of immunosuppressants such as cyclophosphamide can induce long term remission.
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Robert M. Conway (2003) studied Wegener's granulomatosis. Immunosuppressants (e.g., cyclophosphamide) was evaluated. Early diagnosis and instigation of immunosuppressants such as cyclophosphamide can induce long-term remission in Wegener's granulomatosis.
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