What type of study is this?

This is a Meta-Analysis study (also classified as: Randomized Controlled Trials).

September 5, 2025Journal of DiabetesOpen Access

Impact of GLP‐1 Receptor Agonists on Suicide Behavior: A Meta‐Analysis Based on Randomized Controlled Trials

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Meta-analysis of randomized controlled trials finds no significant link between GLP-1 RAs and suicidal behavior in T2DM/obesity.

No significant association found between GLP-1 RA exposure and suicidal behavior in patients with T2DM.
The risk ratio for overall suicidal behavior was 0.84, with a confidence interval of 0.54–1.32.
Subgroup analyses showed no significant differences in suicidal behavior among participants with obesity or adolescents.
Findings highlight that GLP-1 RAs do not increase the risk of suicidal ideation or attempts.

Chen et al. (2025) studied this question.

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