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September 5, 2025Archives of Orthopaedic and Trauma SurgeryOpen Access

Pharmacologic pain management strategies for reducing postoperative pain in total knee arthroplasty: a systematic review from molecular mechanisms to clinical efficiency

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Authors

APAnca Maria PopMHMichael T. Hirschmann

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Overview

Systematic review evaluates analgesic strategies for postoperative pain in total knee arthroplasty, highlighting opioid consumption reductions and efficacy of NSAIDs.

Key Points

  • Duloxetine improved postoperative pain scores after total knee arthroplasty, but lacked clinical relevance.
  • NSAIDs showed an opioid-sparing effect, making them a validated treatment for managing postoperative pain.
  • The analysis indicates that multimodal pain management strategies are essential for improved outcomes following total knee arthroplasty.
  • Opioids, despite being often prescribed, did not demonstrate significant clinical benefits in reducing postoperative pain.

Cite This Study

Pop et al. (2025) studied this question.

synapsesocial.com/papers/68bb49bc6d6d5674bccff6f7https://doi.org/10.1007/s00402-025-06049-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Limiting Postoperative Knee Pain After Total Knee Replacement2022
  2. 2Postoperative Oral Corticosteroids for Pain Management and Recovery After Total Knee Arthroplasty: A Systematic Review2026
  3. 3Effect of oral preemptive analgesia on pain management after total knee arthroplasty: A systematic review and meta-analysis of randomized control trials2025 · 2 citations
  4. 4Rethinking Pain Relief After Surgery2025
  5. 5Pain management in total knee arthroplasty2024