Eksplorasi Ekspresi dan Korelasi Survival Gen PRMT pada Adenokarsinoma Kolon: Pendekatan Data TCGA

Colorectal cancer is one of the leading causes of cancer-related mortality worldwide, with colon adenocarcinoma being its most common histological subtype. Protein arginine methyltransferase (PRMT) genes play important roles in gene regulation and have been implicated in various cancer types. However, the overall expression patterns and prognostic relevance of PRMTs in colon adenocarcinoma remain insufficiently understood. This study aimed to explore the expression and survival association of PRMT genes using transcriptomic data from The Cancer Genome Atlas-Colon Adenocarcinoma (TCGA-COAD). The expression levels of PRMT1 through PRMT9 were compared between tumor and normal tissues. The results showed that PRMT1, PRMT3, PRMT4, PRMT5, and PRMT7 were more highly expressed in tumor tissues in both paired and unpaired analyses. Furthermore, Kaplan-Meier analysis indicated an association between high PRMT3 expression and reduced overall survival. These findings provide a foundation for further research to better understand the biological role of PRMTs, particularly PRMT3, in the development and progression of colon adenocarcinoma, including functional studies and clinical validation.