Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

Edmond A. Rogers; Tyler C. Diorio; Timothy Beauclair; Jhon Martinez; Shatha J. Mufti; David Kim; Nikita Krishnan; Vitaliy L. Rayz; Riyi Shi

doi:10.1039/d5lc00067j

January 1, 2025Lab on a ChipOpen Access

Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

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Key Points

Tau mislocalization to dendritic spines was significantly observed following concussive injuries, indicating a major impact on neuronal health.
Notably, alterations in functional networks were linked to the presence of acrolein and neuronal stress associated with TBI in the model.
The study utilized a TBI-on-a-chip model to replicate the physiological conditions of traumatic brain injuries, providing insights into tau pathology.
These findings suggest that early identification of tau mislocalization could aid in understanding the progression toward Alzheimer's disease.

Implication

Observational analysis reveals tau mislocalization in dendritic spines during TBI, indicating neuronal stress and functional network changes.

Abstract

Traumatic Brain Injuries (TBI) are a risk factor for Alzheimer’s Disease (AD), and share several important pathological features including the development of neurofibrillary tangles (NFT) of tau protein. While this...

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Cite This Study

Rogers et al. (2025) studied this question.

synapsesocial.com/papers/68bb49c46d6d5674bccff868 https://doi.org/10.1039/d5lc00067j

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Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

Key Points

Implication

Abstract

Discussion

Cite This Study

Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip

Key Points

Implication

Abstract

Discussion

Cite This Study

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