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September 5, 2025Journal of Dr. YSR University of Health Sciences.

Microbiological profile and antibiotic-resistance pattern of bacteria isolated from endotracheal secretions of mechanically ventilated patients at a tertiary care hospital

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Authors

RKRehan Nasir KhanQSQursheed SultanaMAMohammed A. R. Ansari

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Overview

Retrospective review identifies Klebsiella pneumoniae as the main pathogen in ICU patients, highlighting antibiotic resistance patterns.

Key Points

  • Klebsiella pneumoniae was the most common bacterium isolated from endotracheal tubes, and 79% of identified organisms were Gram-negative.
  • Among 217 culture samples, 75% were Klebsiella pneumoniae, while MRSA comprised 21% of Gram-positive organisms, indicating a significant resistance pattern.
  • Tigecycline and carbapenems showed high sensitivity among Gram-negative isolates, but most were resistant to Amoxyclav and Cefepime.
  • Strict antibiotic policies and infection control measures are essential for managing multidrug-resistant organisms in critically ill patients.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68bb49c46d6d5674bccff86ahttps://doi.org/10.4103/jdrntruhs.jdrntruhs_54_24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Culture profile and antibiogram of infective organisms from endotracheal secretions in mechanically ventilated patients of a tertiary care centre2026
  2. 2BACTERIOLOGICAL PROFILE AND ANTIBIOGRAM OF GRAM-NEGATIVE BACILLI ISOLATED FROM ENDOTRACHEAL TUBE SECRETIONS AND TRACHEAL ASPIRATES FROM PATIENTS ON MECHANICAL VENTILATION: A HOSPITAL-BASED CROSS-SECTIONAL STUDY2024
  3. 3BACTERIOLOGICAL PROFILE AND ANTIBIOGRAM OF AEROBIC BACTERIA ISOLATED FROM PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA ADMITTED IN CRITICAL CARE UNIT OF A MEDICAL COLLEGE IN WEST BENGAL2024
  4. 4Optimizing Diagnosis and Antibiotic Therapy in Ventilator-Associated Pneumonia: A Comparative Study of Tracheal Secretion Cultures in Critically III Patients2025
  5. 5A55-24 Characterization of the Microbiome on Endotracheal Tubes After Short-Term Use by Mechanically Ventilated Patients2026