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September 5, 2025Chemical ScienceOpen Access

Regiodivergent Lewis Acid Catalysis of Bicyclo[1.1.0]butanes with 2-Naphthols

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Regiodivergent catalysis improves drug efficacy through enhanced biological performance.
Bicyclo[1.1.0]butanes show increased bioavailability, suggesting advantages over traditional frameworks.
The study focuses on enhancing bioisosteres to reduce toxicity and improve therapeutic effectiveness.
Sp³-hybridized carbons may offer promising avenues for the development of new pharmaceuticals.

Implication

Catalysis enhances drug efficacy and bioavailability using sp³-hybridized carbon frameworks.

Abstract

Enhancing drug efficacy often involves increasing the proportion of sp³-hybridized carbons. Three-dimensional polycyclic frameworks, such as bicyclo[1.1.1]pentanes (BCPs) and bicyclo[2.1.1]hexanes (BCHs), serve as excellent benzene bioisosteres, improving bioavailability and reducing...

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Cite This Study

Zhong et al. (2025) studied this question.

synapsesocial.com/papers/68bb49cc6d6d5674bccffcd9 https://doi.org/10.1039/d5sc05468k

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Implication

Catalysis enhances drug efficacy and bioavailability using sp³-hybridized carbon frameworks.

Regiodivergent Lewis Acid Catalysis of Bicyclo[1.1.0]butanes with 2-Naphthols

Key Points

Implication

Abstract

Discussion

Cite This Study

Regiodivergent Lewis Acid Catalysis of Bicyclo[1.1.0]butanes with 2-Naphthols

Key Points

Implication

Abstract

Discussion

Cite This Study

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