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September 5, 2025BMJ Public HealthOpen Access

Breakthrough SARS-CoV-2 outcomes in immune-disordered people during the Omicron era: a prospective cohort study

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Authors

MZMackenzie ZendtFCFausto Andres Bustos CarrilloVCViviane Callier

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Overview

Prospective cohort study shows increased breakthrough infection incidence in immune-disordered people, suggesting higher risks for complications.

Key Points

  • IDP had an initial breakthrough infection incidence 8.8 times higher during the Omicron era compared to earlier.
  • 88 initial breakthrough infections occurred among IDP, with an incidence rate of 23.7 per 100 person-years.
  • COVID-19 symptoms were generally mild in both groups, though IDP had a higher frequency of hospitalizations.
  • IDP faced persistent infections, PASC, and reinfections more commonly than healthy volunteers.

Cite This Study

Zendt et al. (2025) studied this question.

synapsesocial.com/papers/68bb49cc6d6d5674bccffcdfhttps://doi.org/10.1136/bmjph-2024-002436
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