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September 5, 2025MedicinaOpen Access

Assessing Fibrosis Progression and Endothelial Dysfunction in SSc-ILD and COPD: An Integrated Biomarker and CT Densitometry Approach

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Observational study examined fibrosis progression and endothelial dysfunction in COPD and SSc-ILD, indicating distinct biomarker profiles.

COPD showed a significant decline in eGFR by 6.76% over one year, contrasting with a smaller decline in SSc-ILD.
ET-1 levels increased significantly in COPD by 83.78%, while SSc-ILD saw only a 23.83% increase, highlighting differences in vascular responses.
Quantitative CT denoted shifts in lung volume and density, with SSc-ILD showing notable pulmonary fibrosis progression despite limited renal impact.
Integrating biomarkers with CT densitometry may clarify organ-specific changes along the pulmo-renal continuum, supporting more expansive research.

Ibrayeva et al. (2025) studied this question.

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September 5, 2025MedicinaOpen Access

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Authors

Observational study examined fibrosis progression and endothelial dysfunction in COPD and SSc-ILD, indicating distinct biomarker profiles.

COPD showed a significant decline in eGFR by 6.76% over one year, contrasting with a smaller decline in SSc-ILD.
ET-1 levels increased significantly in COPD by 83.78%, while SSc-ILD saw only a 23.83% increase, highlighting differences in vascular responses.
Quantitative CT denoted shifts in lung volume and density, with SSc-ILD showing notable pulmonary fibrosis progression despite limited renal impact.
Integrating biomarkers with CT densitometry may clarify organ-specific changes along the pulmo-renal continuum, supporting more expansive research.

Ibrayeva et al. (2025) studied this question.

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