Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
May 20, 2026American Journal of Respiratory and Critical Care Medicine

C39-40 Imaging-Physiology Dissociation and the Role of Pulmonary Vasculature in Systemic Sclerosis-Associated ILD

View Full Paper
Ask AI
Bookmark
Share

Authors

SWS L WalshACA CrasterCWC Wilson

Discussion

Loading...

Member takes

Overview

Randomized trial examines pulmonary vascular effects on lung function in systemic sclerosis patients, suggesting new monitoring strategies.

Key Points

  • This research aims to explore the relationship between imaging biomarkers and functional decline in systemic sclerosis-associated interstitial lung disease (SSc-ILD).
  • Patients with SSc-ILD were identified from a global imaging repository and two UK Healthcare Trusts.
  • Quantitative CT biomarkers, including vascular and fibrotic metrics, were used to evaluate lung structure.
  • Linear regression models assessed associations between baseline CT biomarkers and changes in lung function.
  • Baseline fibrosis extent was inversely correlated with % predicted forced vital capacity (ppFVC, β = -0.89, p < 0.001), but did not predict ppFVC decline (β = -0.03, p = 0.67).
  • Increased normalized pulmonary vascular volume was associated with physiological decline (β = -4.90, p = 0.018).
  • Fibrosis progression and ppFVC decline demonstrated a weak relationship (β = 0.04, p = 0.09), indicating a disconnect between baseline severity and short-term progression.

Cite This Study

Walsh et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fa9f03e14405aa9b138https://doi.org/10.1093/ajrccm/aamag162.2686
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A95-03 Small Increases in Caliper Quantified Volumes of Ground Glass Opacities, Reticular Densities, and Pulmonary Related Vascular Structures on Baseline CT Associate With Increased Transplant/Mortality Risk in Systemic Sclerosis Associated Interstitial Lung Disease2026
  2. 2B23-15 Structure-function Coupling and Quantitative Imaging Biomarkers in Polymyositis Dermatomyositis Associated Interstitial Lung Disease2026
  3. 3AB1210 COMPREHENSIVE ANALYSIS OF CLINICAL FEATURES IN ESTABLISHED SYSTEMIC SCLEROSIS INTERSTITIAL LUNG DISEASE2024
  4. 4Assessing Fibrosis Progression and Endothelial Dysfunction in SSc-ILD and COPD: An Integrated Biomarker and CT Densitometry Approach2025
  5. 5Identification of Clinical and Radiologic Markers of Disease Presentation in Patients with Scleroderma Related Interstitial Lung Disease (SSc-ILD) in a Cohort from Ontario, Canada2026