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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B23-15 Structure-function Coupling and Quantitative Imaging Biomarkers in Polymyositis Dermatomyositis Associated Interstitial Lung Disease

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Authors

SWS L WalshACA CrasterCWC Wilson

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Overview

Randomized trial investigates structure-function coupling in PM/DM-ILD, suggesting CT biomarkers aid monitoring.

Key Points

  • This research aims to clarify the relationship between structural measures from CT imaging and functional progression in PM/DM-ILD.
  • Identified patients from global imaging repository and two UK healthcare trusts.
  • Conducted volumetric evaluation of airways, pulmonary vessels, and fibrosis using deep learning-based CT models.
  • Assessed associations between baseline CT biomarkers and spirometry data using linear regression and mixed-effects models.
  • Baseline fibrosis averaged 14.6%, correlated negatively with baseline ppFVC (β = -0.65, p = 0.005).
  • Fibrosis progression significantly associated with FVC decline (β = 0.043, p = 0.009).
  • Ground-glass opacification showed a non-significant trend towards association with FVC decline (β = -0.64, p = 0.08).

Cite This Study

Walsh et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4ec0f03e14405aa99f4ahttps://doi.org/10.1093/ajrccm/aamag162.2452
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