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September 5, 2025The EMBO JournalOpen Access

Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells

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Authors

YKYağmur KeserCMCamila Metz‐ZumaranZUZina M. Uckeley

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Overview

Observational analysis reveals basal IFN-λ2/3 expression enhances epithelial barrier function, indicating critical regulatory mechanisms.

Key Points

  • Basal IFN-λ2/3 expression is crucial for developing tight junctions in human epithelial cells, ensuring effective barrier integrity.
  • Cells lacking IFN-λ2/3 failed to establish normal barrier function, emphasizing its role in epithelial cell junction formation.
  • This study explores mechanisms, showing that cGAS-STING can detect mitochondrial DNA and regulate IFN-λ2/3 expression.
  • Findings suggest that understanding basal IFN-λ could lead to insights in maintaining epithelial function, especially under steady-state conditions.

Cite This Study

Keser et al. (2025) studied this question.

synapsesocial.com/papers/68bb49db6d6d5674bcd00262https://doi.org/10.1038/s44318-025-00539-5
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