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September 5, 2025Journal of the Egyptian Womenʼs Dermatologic SocietyOpen Access

Nondesmoglein autoantibodies in oral pemphigus vulgaris: implications for diagnosis and disease monitoring

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Authors

NSNaglaa Mohamed El SayedEEEman M EleryanEOEman Osman

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Overview

Prospective case-control study highlights nondesmoglein antibodies' role in diagnosing oral pemphigus vulgaris, indicating their potential benefits.

Key Points

  • Nondesmoglein antibodies significantly decline in oral pemphigus vulgaris patients after treatment, improving diagnostic clarity.
  • Baseline serum antibody titers were significantly higher in patients than in controls, with a p-value <0.001 for all measures.
  • Prospective case-control study design evaluated 16 oral pemphigus vulgaris patients versus 16 healthy controls.
  • Diagnostic potential of non-Dsg Abs for oral pemphigus vulgaris is strong, yet challenges in long-term monitoring arise.

Cite This Study

Sayed et al. (2025) studied this question.

synapsesocial.com/papers/68bb49db6d6d5674bcd0027dhttps://doi.org/10.4103/jewd.jewd_122_24
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of complement in the pathogenesis of postpartum thyroiditis.1994 · 33 citations
  2. 2Correlation of IgG autoantibodies against acetylcholine receptors and desmogleins in patients with pemphigus treated with steroid sparing agents or rituximab2020 · 11 citations
  3. 3The Pathophysiological Significance of Nondesmoglein Targets of Pemphigus Autoimmunity1998 · 112 citations
  4. 4Desmoglein compensation hypothesis fidelity assessment in Pemphigus2022 · 22 citations