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September 5, 2025The Journal of Organic ChemistryOpen Access

To PLP or Not to PLP: Stereodivergent Transaminase-Catalyzed Reactions Directed by Kinetic and Thermodynamic Control

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Authors

MFM. J. T. FitzgeraldXLXiaoyan LiDPDongjie Peng

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Overview

Biocatalytic processes achieve high diastereoselectivity in amine production, indicating control methods are significant.

Key Points

  • A single transaminase can produce either cis or trans cyclohexylamines with >10:1 diastereoselectivity.
  • The study achieved >70% conversion rates while directing the stereochemical outcome through PLP cofactor management.
  • Dynamic kinetic resolution allows conversion of racemic ketones into enriched amines using a single biocatalyst.
  • This method presents significant operational simplicity in achieving stereodivergent outcomes with just one catalyst.

Cite This Study

Fitzgerald et al. (2025) studied this question.

synapsesocial.com/papers/68bb49db6d6d5674bcd00411https://doi.org/10.1021/acs.joc.5c01382
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