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September 5, 2025VirusesOpen Access

Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility

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The outbreak resulted in recurrent papillomatosis among mice, severely impacting health protocols in the facility.
Histological findings revealed lesions with signs of anisocytosis, epithelial dysplasia, and koilocytosis related to MmuPV1 infection.
The source of the MmuPV1 Bethesda strain was traced back to previously used viral samples in the same facility.
Findings highlight the need for improved international protocols on handling MmuPV1 in animal research.

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Report identifies MmuPV1 outbreak leading to papillomatosis in specific pathogen-free mice, suggesting urgent need for standardized protocols.

Majerčiak et al. (2025) studied this question.

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Report identifies MmuPV1 outbreak leading to papillomatosis in specific pathogen-free mice, suggesting urgent need for standardized protocols.