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September 5, 2025BMC Musculoskeletal DisordersOpen Access

Low-Intensity pulsed ultrasound enhances paracrine secretion of IGF and VEGF by bmscs, promoting osteogenesis and angiogenesis

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Authors

JXJia XuCCChenfeng ChenSGShuaiqi Gan

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Overview

This research shows low-intensity pulsed ultrasound enhances IGF and VEGF secretion in MSCs, indicating improved angiogenesis and osteogenesis.

Key Points

  • LIPUS treatment significantly increased IGF-1 and VEGF secretion from bone marrow-derived MSCs, enhancing their function.
  • Conditioned medium from LIPUS-treated MSCs improved proliferation and differentiation in both MSCs and rat aortic endothelial cells.
  • The study utilized in vitro assays to assess the impact of LIPUS on paracrine signaling and its effects on cell behavior.
  • Findings highlight LIPUS's potential as a therapeutic tool for enhancing bone tissue regeneration through MSC modulation.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d196d6d5674bcd00bfehttps://doi.org/10.1186/s12891-025-09027-7
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