CD4 cell count and viral load count association and its joint risk factors among adult TB/HIV co-infected patients: a retrospective follow-up study

The aim of this study was to determine CD4 cell count and viral load count association and its joint clinical risk factors among adult TB/HIV co-infected patients. The purpose of this research was leads to contribute improved planning and execution of screening programs, regular follow-ups, and prevention measures. The baseline variability for viral load ( $$\:1129.934$$ ) was higher than CD4 cell (819.797). Furthermore, the correlation matrix (R) shows that the baseline subject-specific CD4 cell and viral load were negatively correlated (− 0. $$\:5624$$ ). There was also a negative relationship between the subject-specific change CD4 cell and baseline viral load (- $$\:0.8649$$ ), subject-specific baseline CD4 cell, and the patient-specific change of viral load (-0.6513), longitudinal trajectory (association of evolution) for the two random slopes $$\:($$ -0.9413). Then, there was very strong negative relationship between subject-specific change CD4 cell and viral load over time. Visit time \:\:(\:β\:=-0.1694,\:0.0714) , white blood cell \:\:(\:β\:=-0.0645,0.7430) , good \:(\:β\:=-1.2491,\:0.6940) and fair \:(\:β\:=-0.0236,\:0.4109 ) adherence, hemoglobin ≥ 11 g/dl \:(\:β\:=-2.3610,\:0.4870) , baseline CD4 cell ≥ 200 cells/mm3 \:(\:β\:=-1.3694,\:0.6694) , and baseline viral load < 10,000 copies/mL \:(\:β\:=-1.4683,\:0.9541),\: hematocrit \:(\:β\:=0.4875,-0.3649),\: and monocytes of patients \:\:(\:β\:=-0.0274,\:1.0064) were a joint determinates for viral load and CD4 cell, respectively.