This research demonstrates bond formation in triazoles using azides and alkynes, suggesting new pathways for synthesizing complex molecules.
A reaction between azide, alkyne and 2H-azirine resulted in C–C bond formation at position five of 1,2,3-triazole, instead of previously misidentified C–N bond connectivity. The reaction mechanism of this C–C bond formation on the triazole ring was fully explained by employing calibrated QM(DFT-D3) calculations. Functionalization of primary products provided substituted pyrimidine, furan or 1,3-oxazepine.
No takes yet. Share an insight, caveat, or question.
Janecký et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: