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September 5, 2025Open Access

Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia

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Authors

MCMartina CardilloNBNadia BertolaFFFabiana Ferrero

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Overview

Investigation shows CpG and IL-15 boost IL-23R expression in proliferative CLL, implying significant intraclonal heterogeneity.

Key Points

  • CpG and IL-15 stimulation increases IL-23R levels in proliferative CLL fractions, impacting immune response.
  • Higher IL-23R expression in proliferative CLL cells compared to resting fractions indicates asymmetrical receptor distribution.
  • Findings suggest that IL-23 signaling dominates over IL-12, potentially facilitating leukemic cell survival.
  • This imbalance between IL-23 and IL-12Rbeta2 induction points to a vital pathogenic mechanism that could be targeted therapeutically.

Cite This Study

Cardillo et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d206d6d5674bcd00ee2https://doi.org/10.1101/2025.08.27.672649
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