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September 1, 2025Annals of Internal Medicine

In acute ischemic stroke with large core infarct, EVT improves mRS scores but increases symptomatic intracranial hemorrhage at 90 d

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Key Points

EVT significantly improves mRS scores by enhancing recovery at 90 days post-stroke.
The intervention raises the risk of symptomatic intracranial hemorrhage, presenting a critical trade-off.
This acute ischemic stroke analysis highlights the complexities of treatment decisions in large core infarcts.
The finding suggests a need for careful monitoring after EVT, considering both benefits and risks.

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Implication

Evaluating EVT's impact on mRS outcomes in acute ischemic stroke reveals increased hemorrhage risk.

Abstract

Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].

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Cite This Study

Bernard Lo (2025) studied this question.

synapsesocial.com/papers/68bb4d206d6d5674bcd00f36 https://doi.org/10.7326/annals-25-03146-jc

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1In large-core ischemic stroke with onset in the past 24 h, EVT vs. medical therapy improves functional outcomes and reduces mortality at 90 dHuman Clinical Trial · 2026
2Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion with Large Ischemic Core: A Systematic Review and Meta-Analysismeta-analysis · 2026
3Abstract DP292: Endovascular Thrombectomy Enhances Functional Outcomes and Reduces Cerebral Edema in Large Core Stroke Within 24 Hours: An Observational Cohort StudyCohort Study · 2026
4Does the Ischemic Core Really Matter? An Updated Systematic Review and Meta‐Analysis of Large Core Trials After TESLA, TENSION, and LASTE2024 · 21 citations
5Clinical Observation of Infarct Volume ≥150 mL in Endovascular Thrombectomy Treatment2024

More related papers

Endovascular thrombectomy for acute ischemic stroke with a large infarct area: an updated systematic review and meta-analysis of randomized controlled trials2024
Efficacy and Safety of Endovascular Thrombectomy in Large‐Core Infarcts: A Systematic Review and Meta‐Analysis2025
Efficacy and Safety of Endovascular Thrombectomy in Large‐Core Infarcts: A Systematic Review and Meta‐Analysis2025

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