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September 5, 2025Nephrology Dialysis Transplantation

IGFBP-5/TGF-β1-mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis

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Authors

SWShuqiang WangCSChengcheng SongKCKun Chi

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Overview

Co-culture reveals reciprocal signaling between endothelial cells and tubular epithelial cells, implying a role in renal fibrosis.

Key Points

  • Elevated levels of igfbp-5 in CKD patients indicate its role in renal fibrosis progression.
  • Endothelial-specific deletion of igfbp-5 significantly delayed renal fibrosis in murine models.
  • TGF-β1 amplified igfbp-5 expression in endothelial cells, establishing a feedback loop.
  • The IGFBP-5/TGF-β1 signaling axis is critical for promoting fibrogenesis in renal disease.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d206d6d5674bcd01028https://doi.org/10.1093/ndt/gfaf179
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