Nature-Based Hydrogels Combined with Nanoparticles for Bone Regeneration

Bone is a calcified tissue composed of 60% inorganic compounds, 30% organic compounds, and 10% water. Bone exhibits an intrinsic regenerative capacity, enabling it to heal after fractures or adapt during growth. However, in cases of severe injury or extensive tissue loss, this regenerative capacity becomes insufficient, often necessitating bone graft surgeries using autografts or allografts. Conventional grafting approaches present several limitations, driving the development of alternative strategies in tissue engineering. The system of hydrogel–nanoparticles (NPs) represents a new class of biomaterials designed to combine the advantages of both materials while mitigating their drawbacks. This review focuses on a combination of nature-based hydrogels with different types of nanoparticles and discusses their potential applications in bone regeneration.