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September 5, 2025Open Veterinary JournalOpen Access

Host–parasite interaction in latent cerebral toxoplasmosis: The role of cytokine response in a mouse model

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Authors

TATuğçe AnteplıoğluKırıkkale UniversityMTMerve Bışkın TürkmenKırıkkale UniversityEEErva EserKırıkkale University

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Overview

Observational analysis evaluated cytokine responses and immune dynamics in a mouse model, suggesting insights into chronic cerebral toxoplasmosis.

Key Points

  • Immunological shift from pro-inflammatory to regulatory responses was evident by day 180, indicating immune modulation.
  • Histopathological changes such as gliosis and neuronal degeneration peaked at days 30 and 60 before declining significantly.
  • This mouse model of toxoplasma gondii infection provides a platform for exploring host-pathogen interactions in chronic cerebral toxoplasmosis.
  • Dynamic immune cell changes and cytokine expressions were distinctly observed, highlighting the complex immune dynamics involved.

Cite This Study

Antepli̇oğlu et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d276d6d5674bcd0133fhttps://doi.org/10.5455/ovj.2025.v15.i8.18
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Also Consider

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  1. 1Temporal Neuroimmune Changes During Primary and Persistent Experimental Toxoplasmic Encephalitis2026
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  3. 3Histopathological, Immunohistochemical and Molecular Detection of Toxoplasma gondii in Organs and Tissues of Experimentally Infected Mice2024 · 1 citations
  4. 4Acquired Toxoplasma gondii infection leads to retinal microvascular abnormalities in mice2024
  5. 5Contrasting Disease Progression, Microglia Reactivity, Tolerance, and Resistance to Toxoplasma gondii Infection in Two Mouse Strains2024 · 1 citations